WebThe eukaryotic linear motif (ELM) resource (Kumar et al., 2024) enables, among other functional sites, to detect 29 different degron motifs in the query protein and provides their... http://elm.eu.org/instances.html?q=Q9BRQ8
Table 1 . Degron motifs and cancer-associated dysfunction.
WebAn important class of disordered interfaces are the compact mono-partite, short linear motifs (SLiMs, or eukaryotic linear motifs (ELMs)). They are evolutionarily plastic and interact with relatively low affinity due to the limited number of residues that make direct contact with the binding partner. WebThe process of annotating ELMs, including developement of detection methods and evaluation of context information used to formulate discriminating filters and rules. Please cite: The Eukaryotic Linear Motif resource: 2024 release. (PMID: 34718738 ) gray 2021 trail boss
ELM - Detail for LIG_LEDGF_IBM_1
WebOct 29, 2024 · ELM (Eukaryotic Linear Motif) is a freely accessible resource for understanding and exploring the biology of SLiMs. At the core of the resource is a … WebMar 7, 2024 · For example, the experimentally validated TRP120 SUMO motif was identified by the ELM database (MOD_SUMO_for_1). However, there are newly discovered SLiMs that have not been curated in the ELM database such as the Wnt, Notch, and Hh SLiM ligands, suggesting that there are numerous SLiMs remaining to be discovered and … WebSep 23, 2024 · Figure 2 ERVK protease and similar endogenous proteases share eukaryotic linear motifs patterns. Modified OneZoom image illustrating the conservation of ELM motifs in proteases from eukaryotic organisms (Homo sapiens, Macaca fascicularis, Oryctolagus cuniculus, Mus musculus, Nannospalax galili, Puma concolor, Lynx … chocolate gift bags