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RIF1 acts in DNA repair through phosphopeptide recognition of …
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RIF1 acts in DNA repair through phosphopeptide recognition …
WebRelay Module - RIF-1-RPT-LV-120AC/1X21 2903340 Pre-assembled relay module with Push-in connection, consisting of: relay base, power contact relay, plug-in display/interference suppression module, and retaining bracket. Contact type: 1 changeover contact. Input voltage: 120 V AC Ask a Question Where Can I Buy This Item? Show Product Details (PDF) WebRIF1-PP1 protects the origin-binding ORC1 protein from untimely phosphorylation and consequent degradation by the proteasome. Depletion of RIF1 or inhibition of PP1 destabilizes ORC1, thereby reducing origin licensing. Consistent with reduced origin licensing, RIF1-depleted cells exhibit increased spacing between active origins. WebJun 17, 2024 · RIF1 is required for the spatiotemporal pattern of replication in human cells . RIF1 also associates with PP1 phosphatase, which opposes CDC7 and CDK2 kinase activities and prevents the assembly and activation of CMG at licensed origins (8, 9). The work presented here advances these findings by showing that ATR and CHK1 signaling … hip hop crab bar tampa