WebTSP1 (mouse gene, Thbs1) and TSP2 (Thbs2) have both been disrupted in mice and have unique phenotypes associated with each gene. Thbs1 is a regulator of TGF-β in vivo, and these null animals have lower viability and prolonged wound healing. For skeletal phenotypes, this model has spine curvature and craniofacial alterations. Web21 Mar 2024 · RUNX2 (RUNX Family Transcription Factor 2) is a Protein Coding gene. Diseases associated with RUNX2 include Cleidocranial Dysplasia 1 and Metaphyseal Dysplasia With Maxillary Hypoplasia With Or Without Brachydactyly . Among its related pathways are Gene expression (Transcription) and RUNX2 regulates bone development .
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Web9 Jan 2024 · Through binding to CD36, THBS2 regulates a diverse range of activities including angiogenesis, apoptosis and metastasis ( 13, 14 ). THBS2 is an FGF2 ligand that can block FGF2 interaction with proangiogenic receptors, such as heparin or FGFR1 ( 15 ). THBS2 Hep1 peptide can also bind actin to alter cytoskeletal reorganization ( 16 ).
Web22 Jan 2024 · Thbs2 thrombospondin 2 [ (house mouse)] Gene ID: 21826, updated on 22-Jan-2024 Summary Predicted to enable calcium ion binding activity and heparin binding … Web16 Nov 2024 · Collagen type I alpha 2 (COL1A2), which encodes the pro-alpha 2 chain of type I collagen, is a key gene in a 37-gene network that modulates cell motility through interaction with the cytoskeleton. 12 It is noted that COL1A2 is differentially expressed in gastric cancer by complementary DNA (cDNA) microarray. 13 Thrombospondin 2 …
Web1 Jan 2006 · The THBS2 gene is 38,261 bases in size and is composed of 23 exons. Exons 3-22 encode the 5,808 base mRNA. Transcription. Unlike TSP1, TSP2 is less-to-moderately responsive to serum in mouse NIH3T3 and Swiss 3T3 cells respectively. Transcription of THBS2 in some human cancers is suppressed through hypermethylation. Web10 Nov 2024 · Recent cancer studies have found that the thrombospondin (THBS) family, including THBS1, THBS2, THBS3, THBS4, and THBS5, play vital roles in the development and progression of human cancers. However, their relationships with tumor stage, prognosis, and tumor immunity in pan-cancer have not been systematically reported. In the present …
Web2 Nov 2016 · The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix …
Web19 Jan 2024 · THBS2 gene is also responsible for a co-regulation between cluster 3 and clusters 7–8. Gene expression analysis between ductal carcinoma in situ (DCIS) and invasive breast carcinoma (IBC) tissues has indicated that the THBS2 gene is up-regulated during the transition between non-invasive to invasive breast cancer . shrink cottonWeb21 Mar 2024 · THBS2 (Thrombospondin 2) is a Protein Coding gene. Diseases associated with THBS2 include Intervertebral Disc Disease and Back Pain . Among its related pathways are Diseases associated with O-glycosylation of proteins and Metabolism of proteins . … Complete DNA sequence and characterization of a 330-kb VNTR-rich … Complete information for AFDN-DT gene (RNA Gene), AFDN Divergent Transcript, … Complete information for LINC00242 gene (RNA Gene), Long Intergenic Non-Protein … Knockout of this gene in developing rat brain showed that it may be involved in … This gene encodes a conserved, N-glycosylated protein that likely functions … Complete information for LINC01615 gene (RNA Gene), Long Intergenic Non-Protein … Complete information for ENSG00000266896 gene (RNA Gene), … No data available for mRNA expression in embryonic tissues and stem cells from … shrink control managerWeb1 Dec 2000 · Abstract Thrombospondin 2 (TSP2)-null mice, generated by targeted disruption of the Thbs2 gene, display a complex phenotype that is characterized, in part, by a variety of connective tissue abnormalities and increased vascular density in … shrink cotton clothesWebThe expression of CD24 gene had a positive correlation with the expressions of thrombospondin 2 (THBS2) (r(s)=0.26, P<0.05), and had a negative correlation with the expression of epidermal growth factor containing fibulin like extracellular matrix protein 1 (EFEMP1), mesothelin (MSLN) and calbindin 2 (CALB2) (r(s)=-0.31, -0.52, -0.43, P<0.05 ... shrink cotton clothingWebThe recent publication of a 10-gene biomarker panel generates new hope for the prognostication and personalization of therapy in ovarian cancer. Expression of the 10 biomarker genes (AEBP1, COL11A1, COL5A1, COL6A2, LOX, POSTN, SNAI2, THBS2, TIMP3, VCAN) in primary ovarian tumors correlates with metastasis, recurrence and poor survival. shrink cotton pantsWebThbs2-, Tsp-2-, TSP2-Gene: Thbs2 Location: Chr17:14885762-14914497 bp, - strand Genetic Position: Chr17, 8.95 cM, cytoband A3-B Alliance: Thbs2 tm1Bst page Thbs2 tm1Bst /Thbs2 tm1Bst mice show increased flexibility of tail tendons and ligaments such that a … shrink cotton jeansWebResults Based on bioinformatics analyses, THBS2 (FC: 7.14, FDR < 0.0001) has a significantly high expression in GC samples. lncRNAs BAIAP2-AS1, TSIX, and LINC01215 have RNA interaction with THBS2. shrink cotton shorts